The AMR Industry Alliance (the Alliance) brings together the leading biotech, diagnostic, generic and research-based pharmaceutical companies around the shared goal of curbing antimicrobial resistance in the world. Alliance companies are committed to contribute to and measure their efforts in fighting AMR across four key areas: research, appropriate use, access and manufacturing and the environment. In 2018, AMR Alliance generic and research-based pharmaceutical companies agreed on a framework that promotes responsible antibiotic manufacturing and derived Predicted No-Effect Concentrations (PNECs) for antibiotics in surface water that would be protective of ecological receptors and also limit the spread of resistance from manufacturing sites. Since 2018, the Alliance has conducted additional environmental tests on antibiotics, provided guidance to manufacturers on best practices, set default values to use in the absence of data and are furthering the science via targeted research grants. This presentation will provide an overview of the Alliance, the current state of the science related to the spread of resistance related to environmental dimensions of AMR and critical initiatives that will drive change in the manufacturing space.